Bio X Cell体内实验级抗小鼠PD-1单克隆抗体(29F.1A12)在圈子里属于抗体界的“iPhone”,问世以来受到很多客户的青睐,但很少有人对其产品参数进行详细整理与对比。因此,我们将美国市场上知名的体内实验级抗小鼠PD-1单克隆抗体(克隆号29F.1A12)品牌Syd Labs、Leinco与Bio X Cell体内实验级抗小鼠PD-1单克隆抗体(Clone 29F.1A12)进行了重点比较(数据和信息均来源于官方网站,年份:2024年):
Syd Labs In Vivo Grade Recombinant Anti-mouse PD-1 Rat IgG2a Kappa Monoclonal Antibody (Clone 29F.1A12.1)
级别:in vivo grade
来源:CHO cells,recombinant
同种型:Rat IgG2a Kappa
内毒素:< 1 EU/mg protein as determined by LAL method
纯度:>95% by SDS-PAGE under reducing conditions
国内库存:是
价格:
Syd Labs In Vivo Grade Recombinant Anti-mouse PD-1 Rat IgG2a Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.r2a,1 mg:150美金
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Rat IgG2a Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.r2a,5 mg:275美金
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Rat IgG2a Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.r2a,25 mg:900美金
Bio X CellInVivoPlus anti-mouse PD-1 (CD279)
级别:in vivo grade
来源:hybridoma
同种型:Rat IgG2a Kappa
内毒素:< 1 EU/mg protein as determined by LAL method
纯度:>95% Determined by SDS-PAGE
国内库存:不确定
价格:
Bio X Cell InVivoPlus anti-mouse PD-1 (CD279)货号BP0273,5 mg:781美金
Bio X Cell InVivoPlus anti-mouse PD-1 (CD279)货号BP0273,25 mg:2615美金
Bio X Cell InVivoPlus anti-mouse PD-1 (CD279)货号BP0273,50 mg:3936美金
Bio X Cell InVivoPlus anti-mouse PD-1 (CD279)货号BP0273,100 mg:5568美金
Bio X Cell InVivoMAb anti-mouse PD-1 (CD279)
级别:in vivo grade
来源:hybridoma
同种型:Rat IgG2a Kappa
内毒素:<2EU/mg protein as determined by LAL method
纯度:>95% Determined by SDS-PAGE
国内库存:不确定
价格:
Bio X Cell InVivoMAb anti-mouse PD-1 (CD279)货号BE0273,1 mg:164美金
Bio X Cell InVivoMAb anti-mouse PD-1 (CD279)货号BE0273,5 mg:600美金
Bio X Cell InVivoMAb anti-mouse PD-1 (CD279)货号BE0273,25 mg:2009美金
Bio X Cell InVivoMAb anti-mouse PD-1 (CD279)货号BE0273,50 mg:3024美金
Bio X Cell InVivoMAb anti-mouse PD-1 (CD279)货号BE0273,100 mg:4280美金
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – Purified in vivo GOLD™ Functional Grade
级别:in vivo grade
来源:hybridoma
同种型:Rat IgG2a Kappa
内毒素:< 1 EU/mg protein as determined by LAL method
纯度:>95% by SDS-PAGE
国内库存:不确定
价格:
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – Purified in vivo GOLD™ Functional Grade货号P377,1 mg:105美金
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – Purified in vivo GOLD™ Functional Grade货号P377,5 mg:360美金
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – Purified in vivo GOLD™ Functional Grade货号P377,25 mg:1150美金
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – Purified in vivo GOLD™ Functional Grade货号P377,50 mg:1825美金
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – Purified in vivo GOLD™ Functional Grade货号P377,100 mg:2575美金
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – Purified in vivo PLATINUM™ Functional Grade
级别:in vivo grade
来源:hybridoma
同种型:Rat IgG2a Kappa
内毒素:< 0.5 EU/mg protein as determined by LAL method
纯度:>95% by SDS-PAGE
国内库存:不确定
价格:
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – Purified in vivo PLATINUM™ Functional Grade货号P378,1 mg:240美金
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – Purified in vivo PLATINUM™ Functional Grade货号P378,5 mg:455美金
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – Purified in vivo PLATINUM™ Functional Grade货号P378,25 mg:1550美金
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – Purified in vivo PLATINUM™ Functional Grade货号P378,50 mg:2300美金
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – Purified in vivo PLATINUM™ Functional Grade货号P378,100 mg:3300美金
Leinco Anti-Mouse CD279 (PD-1) – Purified (PhenoCyler-Fusion (CODEX)® Ready)
级别:in vivo grade
来源:hybridoma
同种型:Rat IgG2a Kappa
内毒素:没有信息
纯度:没有信息
国内库存:不确定
价格:
Leinco Anti-Mouse CD279 (PD-1) – Purified (PhenoCyler-Fusion (CODEX)® Ready)货号P501,50μg:125美金
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – PE
级别:in vivo grade
来源:hybridoma
同种型:Rat IgG2a Kappa
内毒素:没有信息
纯度:没有信息
国内库存:不确定
价格:
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – PE货号P384,50μg:107美金
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – PE货号P384,200μg:275美金
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – Purified
级别:in vivo grade
来源:hybridoma
同种型:Rat IgG2a Kappa
内毒素:没有信息
纯度:没有信息
国内库存:不确定
价格:
Leinco Anti-Mouse CD279 (PD-1) (Clone 29F.1A12) – Purified货号P383,0.5mg:107美金
Syd Labs In Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2c-L234A L235A P329G (LALAPG) Kappa Monoclonal Antibody (Clone 29F.1A12.1)
级别:in vivo grade
来源:CHO cells,recombinant
同种型:mouse IgG2c, kappa
内毒素:< 1 EU/mg protein as determined by LAL method
纯度:>95% by SDS-PAGE under reducing conditions
国内库存:是
价格:
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2c-L234A L235A P329G (LALAPG) Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.m2cLA,1 mg:150美金
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2c-L234A L235A P329G (LALAPG) Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.m2cLA,5 mg:275美金
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2c-L234A L235A P329G (LALAPG) Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.m2cLA,25 mg:900美金
Syd Labs In Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2c Kappa Monoclonal Antibody (Clone 29F.1A12.1)
级别:in vivo grade
来源:CHO cells,recombinant
同种型:mouse IgG2c, kappa
内毒素:< 1 EU/mg protein as determined by LAL method
纯度:>95% by SDS-PAGE under reducing conditions
国内库存:是
价格:
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2c Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.m2c,5 mg:400美金
Bio X Cell、Leinco:mouse IgG2c, kappa没有信息
Syd Labs In Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2a-L234A L235A P329G (LALAPG) Kappa Monoclonal Antibody (Clone 29F.1A12.1)
级别:in vivo grade
来源:CHO cells,recombinant
同种型:Mouse IgG2a Kappa
内毒素:< 1 EU/mg protein as determined by LAL method
纯度:>95% by SDS-PAGE under reducing conditions
国内库存:是
价格:
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2a-L234A L235A P329G (LALAPG) Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.m2aLA,1 mg:150美金
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2a-L234A L235A P329G (LALAPG) Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.m2aLA,5 mg:275美金
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2a-L234A L235A P329G (LALAPG) Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.m2aLA,25 mg:900美金
Syd Labs In Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2a Kappa Monoclonal Antibody (Clone 29F.1A12.1)
级别:in vivo grade
来源:CHO cells,recombinant
同种型:Mouse IgG2a Kappa
内毒素:< 1 EU/mg protein as determined by LAL method
纯度:>95% by SDS-PAGE under reducing conditions
国内库存:是
价格:
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2a Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.m2a,1 mg:150美金
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2a Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.m2a,5 mg:400美金
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2a Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.m2a,25 mg:1100美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279)
级别:in vivo grade
来源:hybridoma
同种型:Mouse IgG2a Kappa
内毒素:<1EU/mg protein as determined by LAL method
纯度:>95% Determined by SDS-PAGE
国内库存:不确定
价格:
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279)货号CP159,1 mg:224美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279)货号CP159,5 mg:868美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279)货号CP159,25 mg:3030美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279)货号CP159,50 mg:4356美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279)货号CP159,100 mg:6087美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279) (LALA-PG)
级别:in vivo grade
来源:hybridoma
同种型:Mouse IgG2a Kappa
内毒素:<1EU/mg protein as determined by LAL method
纯度:>95% Determined by SDS-PAGE
国内库存:不确定
价格:
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279) (LALA-PG)货号CP155,1 mg:224美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279) (LALA-PG)货号CP155,5 mg:868美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279) (LALA-PG)货号CP155,25 mg:3030美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279) (LALA-PG)货号CP155,50 mg:4356美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279) (LALA-PG)货号CP155,100 mg:6087美金
Leinco:Mouse IgG2a Kappa没有信息
Syd Labs In Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG1-D265A Kappa Monoclonal Antibody (Clone 29F.1A12.1)
级别:in vivo grade
来源:CHO cells,recombinant
同种型:Mouse IgG1 Kappa
内毒素:< 1 EU/mg protein as determined by LAL method
纯度:>95% by SDS-PAGE under reducing conditions
国内库存:是
价格:
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG1-D265A Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.m1DA,1 mg:150美金
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG1-D265A Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.m1DA,5 mg:400美金
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG1-D265A Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.m1DA,25 mg:1100美金
Syd Labs In Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG1 Kappa Monoclonal Antibody (Clone 29F.1A12.1)
级别:in vivo grade
来源:CHO cells,recombinant
同种型:Mouse IgG1 Kappa
内毒素:< 1 EU/mg protein as determined by LAL method
纯度:>95% by SDS-PAGE under reducing conditions
国内库存:是
价格:
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG1 Kappa Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.m1,5 mg:400美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279)
级别:in vivo grade
来源:hybridoma
同种型:Mouse IgG1 Kappa
内毒素:<1EU/mg protein as determined by LAL method
纯度:>95% Determined by SDS-PAGE
国内库存:不确定
价格:
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279)货号CP178,1 mg:224美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279)货号CP178,5 mg:868美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279)货号CP178,25 mg:3030美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279)货号CP178,50 mg:4356美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279)货号CP178,100 mg:6087美金
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279) (D265A)
级别:in vivo grade
来源:hybridoma
同种型:Mouse IgG1 Kappa
内毒素:<1EU/mg protein as determined by LAL method
纯度:>95% Determined by SDS-PAGE
国内库存:不确定
价格:
Bio X Cell RecombiMAb anti-mouse PD-1 (CD279) (D265A)货号CP005,1mg:515美金
Leinco:Mouse IgG1 Kappa没有信息
Syd Labs In Vivo Grade Recombinant Anti-mouse PD-1 Rabbit IgG Monoclonal Antibody (Clone 29F.1A12.1)
级别:in vivo grade
来源:CHO cells,recombinant
同种型:Rabbit IgG
内毒素:< 1 EU/mg protein as determined by LAL method
纯度:>95% by SDS-PAGE under reducing conditions
国内库存:是
价格:
Syd LabsIn Vivo Grade Recombinant Anti-mouse PD-1 Rabbit IgG Monoclonal Antibody (Clone 29F.1A12.1)货号PA007163.rt,5 mg:595美金
Bio X Cell、Leinco:Rabbit IgG没有信息
Syd Labs体内实验级抗小鼠PD-1单克隆抗体(29F.1A12) 货号:PA007163.m2a
Bio X Cell体内实验级抗小鼠PD-1单克隆抗体(Clone 29F.1A12)与Syd Labs、Leinco可以至少从三个方面进行比较:
第一、用CHO细胞生产重组抗体和杂交瘤生产抗体质量不同。Syd Labs生产的重组抗体采用抗体药物生产中常用的化学成分确定的培养基和CHO细胞,没有来自小鼠腹水和细胞培养基里FBS的抗体污染,同时也没有杂交瘤天然的批次之间的不稳定性。Bio X Cell和Leinco运用杂交瘤细胞培养的方法生产单抗,这个系统的差异决定了其单抗质量不如Syd Labs的重组抗体。
第二、重组抗体还可以进行自由工程改造,包括切换isotype、Fc突变、提升亲和力和产量、人源化或小鼠源化以降低免疫原性。Bio X Cell也提供重组抗体,但是其价格比Syd Labs重组抗体高很多,而品种远没有Syd Labs重组抗体多,给客户的选择就少。
第三、同等内毒素水平的前提下,Syd Labs体内实验级抗小鼠PD-1单克隆抗体(克隆号29F.1A12)价格比Bio X Cell体内实验级抗小鼠PD-1单克隆抗体便宜高达2.4倍以上,比Leinco体内实验级抗小鼠PD-1单克隆抗体便宜高达72%;Syd Labs内毒素<1 EU/mg蛋白质价格甚至比Bio X Cell内毒素<2 EU/mg蛋白质价格还便宜高达1.9倍以上;对于绝大多数动物实验来说,内毒素<1 EU/mg蛋白质就足够了,而内毒素<0.5 EU/mg蛋白质和内毒素<1 EU/mg蛋白质这样的质量差异对于实际应用的重要性有多大,目前没有任何数据支持,个人觉得没有必要做到这个级别。根据部分客户动物实验注射溶液对低内毒素的要求,Syd Labs重组单抗内毒素可低至<0.05 EU/mg蛋白质(FDA对临床产品的质量要求),这是当前科研抗体内毒素水平的天花板。
Bio X Cell体内实验级抗小鼠PD-1单克隆抗体(Clone 29F.1A12)与Syd Labs、Leinco 2024年产品参数进行对比后,不难得出结论: 重组科研抗体第一品牌Syd Labs体内实验级抗小鼠PD-1单克隆抗体(克隆号29F.1A12)性价比最高、选择更多。如果你有不同意见或者更多资料,欢迎留言。
特别声明:本文涉及的所有产品仅限于科研使用,不得用于人类或动物的诊断或治疗。
货号KappaBiomgSyd发布于:湖北省声明:该文观点仅代表作者本人,搜狐号系信息发布平台,搜狐仅提供信息存储空间服务。